The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

  • Lipid transport
  • Response to nutrient
  • Excretion
  • Response to ionizing radiation
  • Negative regulation of intestinal phytosterol absorption
  • Sitosterolemia 2
  • Sitosterolemia
  • Homozygous familial hypercholesterolemia
  • Sitosterolemia 1
  • Short-rib thoracic dysplasia 15 with polydactyly

ABCG5 Localizations – Subcellular Localization Database

Gene Location