This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Tumor type associations:

  • Bladder
  • Breast
  • Cervical
  • Colorectal
  • Endometrial
  • Esophageal
  • Gastric
  • Kidney
  • Liver
  • Lymphoma
  • Melanoma
  • Ovarian
  • Pancreatic
  • Prostate
  • Involved in MAPK cascade
  • Positive regulation of protein phosphorylation
  • Myeloid progenitor cell differentiation
  • Involved in protein phosphorylation
  • Signal transduction
  • Located in nucleus
  • Cytoplasm
  • Mitochondrion
  • Located in cytosol
  • Located in plasma membrane
  • Nucleotide binding
  • Catalytic activity
  • Enables protein kinase activity
  • Enables protein serine/threonine kinase activity
  • Enables MAP kinase kinase activity
  • Cardiofaciocutaneous syndrome 1
  • Adenocarcinoma of lung
  • Nonsmall cell lung cancer
  • Noonan syndrome 7
  • Leopard syndrome 3
  • Noonan syndrome with multiple lentigines
  • Colorectal cancer
  • Melanoma, malignant

BRAF localizations – Subcellular Localization Database

Emw. Structure of the BRAF protein. Based on PyMOL rendering of PDB 1uwh.

Gene Location