This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]

  • G2/M transition of mitotic cell cycle
  • MAPK cascade
  • Microtubule cytoskeleton organization
  • Response to amphetamine
  • Regulation of heart rate
  • Long qt syndrome 14
  • Ventricular tachycardia, catecholaminergic polymorphic, 4
  • Catecholaminergic polymorphic ventricular tachycardia
  • Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy
  • Long qt syndrome 1

CALM3 localizations – Subcellular Localization Database

Emw. Structure of the CALM1 protein. Based on PyMOL rendering of PDB 1a29.

Gene Location