CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Lung Cancer Susceptibility 3 and Adenosquamous Prostate Carcinoma. Among its related pathways are DNA Damage and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.
Tumor type associations:
- Bladder
- Breast
- Cervical
- Colorectal
- Endometrial
- Esophageal
- Gastric
- Kidney
- Melanoma
- Ovarian
- Pancreatic
- Prostate
- Nucleotide binding
- Enables protein kinase activity
- Protein serine/threonine kinase activity
- Enables cyclin-dependent protein serine/threonine kinase activity
- Enables protein serine/threonine/tyrosine kinase activity
- Part of cyclin-dependent protein kinase holoenzyme complex
- Part of cyclin K-CDK12 complex
- Is active in nucleus
- Located in nucleoplasm
- Part of cyclin/CDK positive transcription elongation factor complex
- Involved in transcription elongation from RNA polymerase II promote
- Involved in mRNA processing
- Involved in protein phosphorylation
- Involved in RNA splicing
- Phosphorylation
CDK12 localizations – Subcellular Localization Database
Gene Location
