This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

  • Positive regulation of acute inflammatory response
  • Regulation of transcription, DNA-templated
  • Response to unfolded protein
  • Endoplasmic reticulum unfolded protein response
  • Positive regulation of transcription by RNA polymerase II
  • Spondyloepimetaphyseal dysplasia, strudwick type
  • Platyspondylic lethal skeletal dysplasia, torrance type
  • Hepatocellular carcinoma
  • Otospondylomegaepiphyseal dysplasia, autosomal recessive

CREB3L3 Localizations – Subcellular Localization Database