This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5′-CGGA[AT]-3′. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
- Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA binding
- Enables DNA-binding transcription factor activity
- Located in chromatin
- Is active in nucleus
- Regulation of transcription, DNA-templated
- Involved in regulation of transcription by RNA polymerase II
- Involved in transcription by RNA polymerase II
- Involved in axon guidance
- Involved in muscle organ development
ETV1 Localizations – Subcellular Localization Database