The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]

  • Angiogenesis
  • Cell fate determination
  • Negative regulation of cell-matrix adhesion
  • Blood vessel remodeling
  • Morphogenesis of an epithelial sheet
  • Alagille syndrome 1
  • Deafness, congenital heart defects, and posterior embryotoxon
  • Tetralogy of fallot
  • Atypical coarctation of aorta
  • Rare congenital non-syndromic heart malformation

JAG1 Localizations – Subcellular Localization Database

Structure of protein JAG1.Based on PyMOL rendering of PDB 2KB9. Pleiotrope.

Gene Location