The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

  • Nucleotide binding
  • Protein kinase activity
  • Protein serine/threonine/tyrosine kinase activity
  • Enables protein tyrosine kinase activity
  • Enables transmembrane receptor protein tyrosine kinase activity
  • Located in extracellular region
  • Located in nucleus
  • Located in cytoplasm
  • Lysosome
  • Located in Golgi apparatus
  • Located in plasma membrane
  • Involved in angiogenesis
  • Involved in glycosaminoglycan biosynthetic process
  • Protein phosphorylation
  • Chemotaxis
  • Involved in signal transduction

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands – homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

  • Sorafenib
  • Sunitinib
  • Pazopanib
  • Imatinib
  • Dasatinib
  • Regorafenib
  • Nintedanib
  • Becaplermin
  • Midostaurin
  • Erdafitinib
  • Foreskin fibroblast (neonatal)
  • Fostamatinib
  • Pexidartinib
  • Pralsetinib
  • Ripretinib
  • Tivozanib
  • Axitinib
  • Lenvatinib
  • Nilotinib
  • Ponatinib
  • Rabeprazole
  • Romiplostim
  • Vandetanib
  • Abnormality of body height
  • Autosomal dominant inheritance
  • Functional abnormality of the bladder
  • Abnormality of the bladder
  • Urinary incontinence
  • Abnormality of the kidney
  • Abnormality of the urinary system
  • Tall stature
  • Abnormality of the genitourinary system
  • Abnormality of head or neck
  • Abnormality of the mouth
  • Abnormal lip morphology
  • Abnormal oral cavity morphology
  • Abnormality of the dentition
  • Abnormality of the gingiva
  • Gingival fibromatosis
  • Abnormality of upper lip
  • Thin upper lip vermilion
  • Thin vermilion border
  • Abnormality of the head
  • Abnormality of the fontanelles or cranial sutures
  • Abnormality of skull size
  • Microcephaly
  • Delayed cranial suture closure
  • Abnormality of the face
  • Abnormal mandible morphology
  • Abnormality of the forehead
  • Mask-like facies
  • Abnormality of the chin
  • Pointed chin
  • Abnormality of the midface

PDGFRB Localizations – Subcellular Localization Database

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

  • Nucleotide binding
  • Protein kinase activity
  • Protein serine/threonine/tyrosine kinase activity
  • Enables protein tyrosine kinase activity
  • Enables transmembrane receptor protein tyrosine kinase activity
  • Located in extracellular region
  • Located in nucleus
  • Located in cytoplasm
  • Lysosome
  • Located in Golgi apparatus
  • Located in plasma membrane
  • Involved in angiogenesis
  • Involved in glycosaminoglycan biosynthetic process
  • Protein phosphorylation
  • Chemotaxis
  • Involved in signal transduction

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands – homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

  • Sorafenib
  • Sunitinib
  • Pazopanib
  • Imatinib
  • Dasatinib
  • Regorafenib
  • Nintedanib
  • Becaplermin
  • Midostaurin
  • Erdafitinib
  • Foreskin fibroblast (neonatal)
  • Fostamatinib
  • Pexidartinib
  • Pralsetinib
  • Ripretinib
  • Tivozanib
  • Axitinib
  • Lenvatinib
  • Nilotinib
  • Ponatinib
  • Rabeprazole
  • Romiplostim
  • Vandetanib
  • Abnormality of body height
  • Autosomal dominant inheritance
  • Functional abnormality of the bladder
  • Abnormality of the bladder
  • Urinary incontinence
  • Abnormality of the kidney
  • Abnormality of the urinary system
  • Tall stature
  • Abnormality of the genitourinary system
  • Abnormality of head or neck
  • Abnormality of the mouth
  • Abnormal lip morphology
  • Abnormal oral cavity morphology
  • Abnormality of the dentition
  • Abnormality of the gingiva
  • Gingival fibromatosis
  • Abnormality of upper lip
  • Thin upper lip vermilion
  • Thin vermilion border
  • Abnormality of the head
  • Abnormality of the fontanelles or cranial sutures
  • Abnormality of skull size
  • Microcephaly
  • Delayed cranial suture closure
  • Abnormality of the face
  • Abnormal mandible morphology
  • Abnormality of the forehead
  • Mask-like facies
  • Abnormality of the chin
  • Pointed chin
  • Abnormality of the midface

PDGFRB Localizations – Subcellular Localization Database

L.A.Metskas. Ribbon image of human PDGF receptor beta in complex with PDGF-B. This image was created using Pymol, based on 3MJG in the Protein Data Bank.

Gene Location