This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]

  • Negative regulation of transcription by RNA polymerase II
  • Regulation of transcription by RNA polymerase II
  • Cell differentiation
  • Positive regulation of osteoblast differentiation
  • Negative regulation of transcription, DNA-templated

Emw. Structure of the ZHX3 protein. Based on PyMOL rendering of PDB 2da5.

Gene Location