This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]

  • Heart looping
  • Regulation of transcription by RNA polymerase II
  • Multicellular organism development
  • Determination of left/right symmetry
  • Pattern specification process
  • Heterotaxy, visceral, 1, x-linked
  • Vacterl association, x-linked, with or without hydrocephalus
  • Vacterl association with hydrocephaly, x-linked
  • Heterotaxy
  • Vacterl association

Pleiotrope. Structure of protein ZIC3.Based on PyMOL rendering of PDB 2EJ4.

Gene Location