The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

  • Cell surface receptor signaling pathway
  • Cell-cell signaling
  • Nervous system development
  • Muscle organ development
  • Positive regulation of cell proliferation
  • Dilated cardiomyopathy
  • Leukemia
  • Hypertensive heart disease
  • Neonatal stroke
  • Motor neuron disease