A Few Drops of Blood Hormone Testing

Highly Specific and Sensitive Mass Spectrometry Detection:

Mass Spectrometry Detect, Differentiate Quantitate Hormones in Small Volume Blood. We have developed the first LC/MS based method for the detection and measurement of 28 different hormones using SVB.

Aldosterone
Androstenedione
Cortisol
Corticosterone
Cortisone
11-Deoxycorticosterone
11-Deoxycortisol
21-Deoxycortisol
Dehydroepiandrosterone(DHEA)
17α-Hydroxyprogesterone
Epitestosterone
Estriol
Estrone
Progesterone
Testosterone
1α,25-hydroxyvitamin D3
Cholesterol
25-hydroxyvitamin D3
T3, 3,3′,5-TRIIODO-L-THYRONINE (T3)
T4, L-THYROXINE
DHEA Sulfate
5α-Dihydrotestosterone (DHT)
Pregnenolone
17-Hydroxypregnenolone Hyperglycosyla
17α-Ethynylestradiol
Equilin
2-Hydroxyestrone
Estradiol or 17β-Estradiol

A new generation of diagnostic testing allows us to perform tests with small amount of blood. Using as little as a few drops of blood (0.5 ml for SVB versus 10 ml for Venous) collected from a single finger prick we are able to detect and quantitate the levels of various hormones.

Low quantities of hormones circulate in the blood. Hormone concentrations can be as low as one billionth of a milligram. Accurate measurement of hormones require very sensitive assays. A small volume blood (serum) test provides a sensitive assessment of circulating hormones with well-established measurement reference ranges. The high sensitivity and high throughput of our analyzer enables reproducible and accurate quantification.

Lower Cost Hormone Testing

The list of 28 hormones includes steroid hormones and peptide hormones. Steroid hormones are in turn divided into mineralocorticoids, glucocorticoids, and gonadocorticoids (sex steroids).

The test is developed to detect the hormones their precursors and bi-product and shows 100% correlation between Venipuncture and Finger-Prick Blood Results.

Classification:

Blood Pressure Regulation
Autonomic Nervous System

A steroid hormone made by the adrenal glands that affects blood pressure and helps regulate sodium and potassium levels in the blood. The test is used to diagnose fluid and electrolyte disorders that might be caused by:

Heart Problems
Kidney Failure
Diabetes
Adrenal Disease

It can also help diagnose:

High blood pressure that is hard to control or occurs at a young age
Low blood pressure caused by standing up
Under active adrenal glands when the levels are low

Classification:

Anabolic

A steroid hormone made by the adrenal glands and gonads. It is formed during the production of testosterone and estrogen. The production of Androstenedione by the adrenal glands is controlled by Adrenocorticotropic hormone whereas its production in the gonads is controlled by luteinizing hormone and follicle stimulating hormone.

The test is used to:

Help evaluate the function of the adrenal gland.
Detect adrenal tumors.
Evaluate the development of masculine physical characteristics in a woman or early puberty in boys.
Evaluate androgen production and function of ovaries in women or testicular function in men.
Diagnose with Congenital Adrenal Hyperplasia (CAH) and monitor treatment for CAH.
Diagnose with Polycystic ovary syndrome (PCOS) 

Classification:

Metabolism
Immune System
Sleep
Nervouse System
Stress

A steroid hormone that affects almost every organ in the body and is made by the adrenal glands. It plays an important role in responding to stress, fighting infection, regulating blood sugar, maintaining blood pressure and regulating metabolism.

The test is used for:

Diagnose with Cushing’s syndrome, a condition that causes the body to produce too much cortisol and is characterized by:
Obesity, especially in the torso
High Blood Pressure
High Blood Sugar
Muscle Weakness
Purple streaks on the stomach
Skin Bruising Easily
Women with irregular menstrual periods and excess hair on the face

Diagnose with Addison disease, a condition that causes the body to produce not enough cortisol and is characterized by:

Weight loss
Fatigue
Muscle weakness
Abdominal pain
Dark patches of skin
Low blood pressure
Nausea and vomiting
Diarrhea
Decreased body hair

Classification:

Memory
Stress
Nervous System

A steroid hormone that is a precursor for aldosterone and is made in the adrenal glands and gonads. The major diagnostic utility of this hormone and other steroid intermediates is for Congenital Adrenal Hyperplasia (CAH).

Measurement of corticosterone is used as an adjunct to 11-deoxycorticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Inflammation

A steroid hormone made by the adrenal glands in response to stress. It elevates blood pressure and prepares the body for a fight or flight response. Cortisone can be considered an inactive metabolite of cortisol. It could also be a precursor due to the reverse reaction that is catalyzed by an enzyme known as 11-beta-steroid dehydrogenase.
The test is used:

For the evaluation adrenal insufficiency (decreased levels).
As a marker for apparent mineralocorticoid excess (AME) (decreased levels).
As a marker for exogenous steroid use.

Classification:

Blood Pressure Regulation

A steroid hormone produced by the adrenal glands and gonads. It is the last intermediate in the mineralocorticoid pathway with negligible activity. It is then converted to the first mineral corticoids with significant activity, corticosterone, which in turn is converted to aldosterone. The major diagnostic utility of this hormone is for Congenital Adrenal Hyperplasia (CAH).
Measurement of 11-deoxycorticosterone is used as an adjunct to corticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Blood Pressure Regulation
Immune System

Also known as compound S, is a hormone produced by the adrenal gland and is the immediate precursor of cortisol. The major diagnostic utility of this hormone and other steroid intermediates is for Congenital Adrenal Hyperplasia (CAH).
Measurement of 11-deoxycorticosterone is used as an adjunct to corticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Metabolism
Immune System

A steroid hormone produced by the adrenal glands and gonads. While the main product of the glucocorticoid pathway is cortisol, a small portion is converted to 21-deoxycortisol, which in turn can be converted to cortisol by the action of the enzyme CYP21A2. The major diagnostic utility of this hormone is for Congenital Adrenal Hyperplasia (CAH) presumed to be due to CYP21A2 deficiency.

Classification:

Gonads
Metabolism
Nervous System

A steroid hormone produced by the adrenal glands, gonads and the brain. It is an important precursor in the synthesis of sex steroids.
The test is used for:
Diagnosis of hyperandrogenism (in combination with other sex steroids).
General screening in adults together with testosterone and sex hormone-binding globulin measurement.
Diagnosis of Congenital Adrenal Hyperplasia (CAH) together with other steroids.

Classification:

Pregnancy
Gonads

An endogenous steroid hormone that is derived from progesterone and is produced by the adrenal glands and gonads. It is a precursor for the synthesis of other endogenous steroids such as androgens, estrogens, glucocorticoids and mineralocorticoids.
The test is used for the diagnosis of Congenital Adrenal Hyperplasia (CAH) in combination with two other steroid hormones, cortisol and androstenedione. The typical enzymes that are defective (21-hydroxylase and 11β-hydroxylase) in CAH lead to a build-up of 17α-hydroxyprogesterone.

Classification:

Anabolic
Prostate

An endogenous steroid hormone that is an epimer of testosterone and is produced by the adrenal gland and gonads. Its levels are the highest in young men, however by adulthood healthy males exhibit a testosterone to epitestosterone ratio (T/E ratio) of about 1:1.
This test is used to detect anabolic steroid abuse and distinguish between testosterone that is produced naturally versus testosterone derived from drugs or supplements. The National Commission for Certifying Agencies currently uses a ratio of testosterone to epitestosterone of 6:1 and a ratio of T/E that is greater than 6 is considered as evidence of anabolic steroid abuse.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estradiol Classification:

Gonads
Bone
Nervous System
Gynecological Cancers
Blood Clotting

An endogenous steroid hormone produced by the gonads, adrenal glands, liver, fat cells and the brain. It is the major female sex hormone that regulates estrous and menstrual female reproductive cycles.

The test is used for:

Monitoring estrogen replacement therapy together with luteinizing hormone.
Monitoring antiestrogen therapy.
Assisting in in vitro fertilization by assessing the follicle development.
Diagnosis of endrogen-producing neoplasms especially in males.
Assessment of delayed puberty in females.
Assessment of disorders in the overall steroid pathway in conjunction with other steroid hormones.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estriol Classification:

Pregnancy

An endogenous steroid hormone produced mostly by the placenta in pregnant women. In non-pregnant women, it is synthesized in the liver and is quickly cleared from the body leaving the blood with barely detectable levels of the hormone.

This test is used:

As part of the triple test for the assessment of chromosomal or congenital anomalies during pregnancy such as down syndrome.
For the assessment of breast cancer risk in combination with measurement of estrone, and estradiol.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estrone Classification:

Gonads
Gynecological Cancers

An endogenous steroid hormone produced by the gonads.

The test is used for:

Assessment of delayed puberty in females.
Assessment of disorders in the overall steroid pathway in conjunction with other steroid hormones.
Monitoring estrogen replacement therapy together with luteinizing hormone.
Monitoring antiestrogen therapy.

Classification:

Pregnancy
Nervous System

An endogenous steroid hormone produced by the gonads and adrenal glands, in addition to the brain and fat cells to a lesser extent.

The test is used for:

Determining whether ovulation occurred in a menstrual cycle.
Assessment of infertility
Evaluation of abnormal uterine bleeding
Evaluation of placental health in high-risk pregnancy
Determining the effectiveness of progesterone injections when administered to women to help support early pregnancy
Examination for adrenal disorders

Classification:

Gonads
Metabolism
Mood
Prostate

An endogenous steroid hormone produced by the gonads and adrenal glands. It is the primary hormone that stimulates the development of male secondary sexual characteristics. Its main role in females is an estrogen precursor. The majority of testosterone in the blood is bound to sex hormone-binding globulin however the active and bioavailable form of the hormone is free, which is detected by this method.

The test is used for:

Evaluation of hypogonadism in men.
Evaluation of delayed puberty in boys.
Monitoring testosterone replacement therapy.
Evaluation of women or infants with virilization.
Diagnosis of androgen secreting tumors in women.
Evaluation of women with testosterone deficiency.

Classification:

Metabolism
Immune System
Sleep
Nervouse System
Stress

A steroid hormone that affects almost every organ in the body and is made by the adrenal glands. It plays an important role in responding to stress, fighting infection, regulating blood sugar, maintaining blood pressure and regulating metabolism.

The test is used for:

Diagnose with Cushing’s syndrome, a condition that causes the body to produce too much cortisol and is characterized by:
Obesity, especially in the torso
High Blood Pressure
High Blood Sugar
Muscle Weakness
Purple streaks on the stomach
Skin Bruising Easily
Women with irregular menstrual periods and excess hair on the face

Diagnose with Addison disease, a condition that causes the body to produce not enough cortisol and is characterized by:

Weight loss
Fatigue
Muscle weakness
Abdominal pain
Dark patches of skin
Low blood pressure
Nausea and vomiting
Diarrhea
Decreased body hair

Classification:

Memory
Stress
Nervous System

A steroid hormone that is a precursor for aldosterone and is made in the adrenal glands and gonads. The major diagnostic utility of this hormone and other steroid intermediates is for Congenital Adrenal Hyperplasia (CAH).

Measurement of corticosterone is used as an adjunct to 11-deoxycorticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Inflammation

A steroid hormone made by the adrenal glands in response to stress. It elevates blood pressure and prepares the body for a fight or flight response. Cortisone can be considered an inactive metabolite of cortisol. It could also be a precursor due to the reverse reaction that is catalyzed by an enzyme known as 11-beta-steroid dehydrogenase.
The test is used:

For the evaluation adrenal insufficiency (decreased levels).
As a marker for apparent mineralocorticoid excess (AME) (decreased levels).
As a marker for exogenous steroid use.

Classification:

Blood Pressure Regulation

A steroid hormone produced by the adrenal glands and gonads. It is the last intermediate in the mineralocorticoid pathway with negligible activity. It is then converted to the first mineral corticoids with significant activity, corticosterone, which in turn is converted to aldosterone. The major diagnostic utility of this hormone is for Congenital Adrenal Hyperplasia (CAH).
Measurement of 11-deoxycorticosterone is used as an adjunct to corticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Blood Pressure Regulation
Immune System

Also known as compound S, is a hormone produced by the adrenal gland and is the immediate precursor of cortisol. The major diagnostic utility of this hormone and other steroid intermediates is for Congenital Adrenal Hyperplasia (CAH).
Measurement of 11-deoxycorticosterone is used as an adjunct to corticosterone and 11-deoxycortisol measurements in the diagnosis of:

CYP11B1 deficiency (associated with cortisol deficiency)
The less common CYP11B2 deficiency (no cortisol deficiency)
The rare glucocorticoid responsive hyperaldosteronism
Isolated loss of function of the 18-hydroxylase or 18-methyloxidase activity of CYP11B2

Classification:

Metabolism
Immune System

A steroid hormone produced by the adrenal glands and gonads. While the main product of the glucocorticoid pathway is cortisol, a small portion is converted to 21-deoxycortisol, which in turn can be converted to cortisol by the action of the enzyme CYP21A2. The major diagnostic utility of this hormone is for Congenital Adrenal Hyperplasia (CAH) presumed to be due to CYP21A2 deficiency.

Classification:

Gonads
Metabolism
Nervous System

A steroid hormone produced by the adrenal glands, gonads and the brain. It is an important precursor in the synthesis of sex steroids.
The test is used for:
Diagnosis of hyperandrogenism (in combination with other sex steroids).
General screening in adults together with testosterone and sex hormone-binding globulin measurement.
Diagnosis of Congenital Adrenal Hyperplasia (CAH) together with other steroids.

Classification:

Pregnancy
Gonads

An endogenous steroid hormone that is derived from progesterone and is produced by the adrenal glands and gonads. It is a precursor for the synthesis of other endogenous steroids such as androgens, estrogens, glucocorticoids and mineralocorticoids.
The test is used for the diagnosis of Congenital Adrenal Hyperplasia (CAH) in combination with two other steroid hormones, cortisol and androstenedione. The typical enzymes that are defective (21-hydroxylase and 11β-hydroxylase) in CAH lead to a build-up of 17α-hydroxyprogesterone.

Classification:

Anabolic
Prostate

An endogenous steroid hormone that is an epimer of testosterone and is produced by the adrenal gland and gonads. Its levels are the highest in young men, however by adulthood healthy males exhibit a testosterone to epitestosterone ratio (T/E ratio) of about 1:1.
This test is used to detect anabolic steroid abuse and distinguish between testosterone that is produced naturally versus testosterone derived from drugs or supplements. The National Commission for Certifying Agencies currently uses a ratio of testosterone to epitestosterone of 6:1 and a ratio of T/E that is greater than 6 is considered as evidence of anabolic steroid abuse.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estradiol Classification:

Gonads
Bone
Nervous System
Gynecological Cancers
Blood Clotting

An endogenous steroid hormone produced by the gonads, adrenal glands, liver, fat cells and the brain. It is the major female sex hormone that regulates estrous and menstrual female reproductive cycles.

The test is used for:

Monitoring estrogen replacement therapy together with luteinizing hormone.
Monitoring antiestrogen therapy.
Assisting in in vitro fertilization by assessing the follicle development.
Diagnosis of endrogen-producing neoplasms especially in males.
Assessment of delayed puberty in females.
Assessment of disorders in the overall steroid pathway in conjunction with other steroid hormones.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estriol Classification:

Pregnancy

An endogenous steroid hormone produced mostly by the placenta in pregnant women. In non-pregnant women, it is synthesized in the liver and is quickly cleared from the body leaving the blood with barely detectable levels of the hormone.

This test is used:

As part of the triple test for the assessment of chromosomal or congenital anomalies during pregnancy such as down syndrome.
For the assessment of breast cancer risk in combination with measurement of estrone, and estradiol.

Estrogen is the primary female sex hormone and an estrogen test measures any of three forms of the hormone:

Estradiol (E2)
Estriol (E3)
Estrone (E1)

Estrone Classification:

Gonads
Gynecological Cancers

An endogenous steroid hormone produced by the gonads.

The test is used for:

Assessment of delayed puberty in females.
Assessment of disorders in the overall steroid pathway in conjunction with other steroid hormones.
Monitoring estrogen replacement therapy together with luteinizing hormone.
Monitoring antiestrogen therapy.

SMALL VOLUME BLOOD HORMONE PANEL CLASSIFICATION