This test detects IgG antibodies directed against cardiolipin, a phospholipid that plays a role in blood clot formation and vascular health. Elevated levels are strongly associated with Antiphospholipid Syndrome (APS) — an autoimmune condition that increases the risk of abnormal clotting in veins and arteries.
Diagnostic Value: Anti-Cardiolipin IgG is considered the most clinically significant of the cardiolipin antibody group and is included in the formal diagnostic criteria for APS.
Clinical Significance: High levels of IgG cardiolipin antibodies may lead to deep vein thrombosis, pulmonary embolism, stroke, or recurrent pregnancy loss. Persistent positivity in repeat tests (at least 12 weeks apart) confirms a true autoimmune process rather than a temporary infection-related elevation.
Symptom Correlation: Symptoms may include unexplained blood clots, headaches, visual disturbances, or pregnancy complications.
Because of its strong link with clotting disorders and pregnancy loss, the Anti-Cardiolipin IgG test is an essential component in evaluating antiphospholipid-related autoimmune conditions.