Clinically Actionable Pharmacogenetic Tests to Determine Right Medication at the Right Dose
Adverse drug reaction (ADR) is the number four leading cause of death, with cardiac disease the first, cancer the second, and accidents as the third. It is estimated that about 2.2 million hospitalized patients suffer from ADR, resulting in 106,000 annual deaths. One of the causes for ADR is failed drug metabolism that could result in inactive products, leading to therapy failure or toxic metabolites that linger in the body for a longer time, which then lead to adverse side effects.
Pharmacogenetic Testing is shown to provide tailored information for the right medication for a person based on their genetic makeup and to enhance drug efficacy. It allows us to assess the likelihood that an individual will have a normal, reduced, or enhanced response to certain medications. This is very important because it dictates how a person responds to a treatment prior to actually receiving the treatment based on their genetics, improving efficacy and reducing adverse effects.