The Hereditary Cancer panel targets 108 genes and 281 SNPs that have been previously linked to a predisposition to common and rare forms of cancer such as leukemia, ovarian cancer, breast cancer, prostate cancer, pancreatic cancer, lung cancer, and skin cancer. This assay is performed using genomic DNA isolated from human peripheral whole blood specimens or buccal cells from mouthwash sample.
The test is intended to identify the variants that are associated with cancer. It is performed as a pre-symptomatic genetic test in order to determine whether persons with a family history of a cancer, but no current symptoms, has gene alterations associated with the disease. The test can also be used for post-symptomatic genetic testing to gain evidence to confirm variants of association to cancer.