This test detects antibodies that target centromere proteins (CENP-A and CENP-B), found in the nucleus of cells. These antibodies are strongly associated with certain forms of systemic sclerosis (scleroderma), particularly the limited cutaneous type known as CREST syndrome.
Diagnostic Value: A positive Centromere Antibody test supports the diagnosis of limited systemic sclerosis, distinguishing it from diffuse forms of the disease.
Clinical Significance: Patients with these antibodies often have a slower disease progression but a higher likelihood of Raynaud’s phenomenon and esophageal involvement.
Symptom Correlation: Typical signs include tightening of skin on fingers, calcium deposits under skin, esophageal reflux, and dilated capillaries.
Because of its strong disease association and predictive value, the Centromere Antibody test helps guide early detection and targeted management of systemic sclerosis.