This test is a functional clotting assay used to evaluate prolonged clotting times and detect lupus anticoagulant, using silica as a clotting activator instead of snake venom.
Diagnostic Value: It serves as a complementary test to DRVVT, confirming the presence of phospholipid-dependent antibodies that prolong clotting times.
Clinical Significance: A prolonged SCT that corrects with added phospholipids indicates lupus anticoagulant activity, contributing to APS diagnosis.
Symptom Correlation: Patients with positive results may have a history of unexplained thrombosis or pregnancy loss.
Used together with DRVVT, the SCT test provides greater accuracy in detecting lupus anticoagulant, ensuring thorough evaluation of clotting-related autoimmune disorders.