SHBG is a protein that binds sex hormones (testosterone and estrogen), controlling their bioavailability.
Diagnostic Value: High SHBG may indicate hyperthyroidism or liver disease; low SHBG may occur with insulin resistance, obesity, or PCOS.
Clinical Importance: SHBG testing clarifies discrepancies between total and free hormone measurements.
Symptom Correlation: Fatigue, weight gain, or loss of libido may stem from abnormal SHBG levels affecting hormone balance.
It serves as an important regulator in interpreting hormonal test results accurately.