This test detects IgG antibodies against the phosphatidylserine–prothrombin complex, which are associated with abnormal blood clotting and autoimmune activity.
Diagnostic Value: The presence of aPS/PT IgG antibodies supports the diagnosis of Antiphospholipid Syndrome (APS), particularly in patients with unexplained thrombosis or recurrent pregnancy loss.
Clinical Significance: These antibodies can promote hypercoagulability by interfering with natural anticoagulant pathways. Measuring aPS/PT IgG enhances diagnostic sensitivity in patients who are negative for conventional antiphospholipid markers (such as lupus anticoagulant or anticardiolipin antibodies).
Symptom Correlation: Patients may experience deep vein thrombosis, stroke, miscarriages, or chronic headaches linked to vascular inflammation.
Because of its strong association with autoimmune-mediated clotting disorders, the aPS/PT IgG test provides valuable diagnostic and prognostic insight into antiphospholipid conditions.