This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Tumor type associations:
- Bladder
- Cervical
- Colorectal
- Endometrial
- Esophageal
- Gastric
- Kidney
- Lymphoma
- Melanoma
- Ovarian
- Pancreatic
- Prostate
- Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific
- Enables core promoter sequence-specific DNA binding
- Enables transcription coregulator binding
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific
- Located in chromatin
- Located in nucleus
- Nuclear envelope
- Located in nucleoplasm
- Located in nucleolus
- Involved in G1/S transition of mitotic cell cycle
- Involved in negative regulation of transcription by RNA polymerase II
- Involved in MAPK cascade
- Involved in re-entry into mitotic cell cycle
- Involved in ovarian follicle development
- Burkitt lymphoma, somatic
MYC localizations – Subcellular Localization Database
AbsturZ. Crystal structure of Myc and Max in complex with DNA.
Gene Location
