Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Tumor type associations:
- Bladder
- Breast
- Cervical
- Colorectal
- Endometrial
- Esophageal
- Gastric
- Kidney
- Lymphoma
- Melanoma
- Ovarian
- Pancreatic
- Prostate
- Enables phosphotyrosine residue binding MAP kinase kinase activity
- Enables transmembrane receptor protein tyrosine kinase adaptor activity
- Enables insulin receptor binding
- Enables insulin-like growth factor receptor binding
- Enables neurotrophin TRKA receptor binding
- Located in nucleus
- Located in cytoplasm
- Located in cis-Golgi network
- Located in cytosol
- Located in plasma membrane
- Involved in cellular glucose homeostasis
- Involved in negative regulation of cell-matrix adhesion
- Involved in protein phosphorylation
- Involved in protein import into nucleus
- Negative regulation of cell adhesion
- Agammaglobulinemia 7, autosomal recessive
- Immunodeficiency 36
- SHORT syndrome
PIK3R1 localizations – Subcellular Localization Database