This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

  • Nucleotide binding
  • Protein kinase activity
  • Enables protein serine/threonine kinase activity
  • Enables protein serine/threonine/tyrosine kinase activity
  • Enables protein binding
  • Located in nucleus
  • Located in nucleoplasm
  • Cytoplasm
  • Endosome
  • Located in early endosome
  • Involved in positive regulation of protein phosphorylation
  • Carbohydrate metabolic process
  • Glycogen metabolic process
  • Involved in glycogen biosynthetic process
  • Involved in glucose metabolic process

AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with AKT2 include Hypoinsulinemic Hypoglycemia With Hemihypertrophy and Type 2 Diabetes Mellitus. Among its related pathways are Regulation of TP53 Activity and DNA Damage Response (only ATM dependent). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

  • Autosomal dominant inheritance
  • Abnormal morphology of female internal genitalia
  • Abnormality of the genital system
  • Abnormality of reproductive system physiology
  • Abnormality of the genitourinary system
  • Abnormality of the ovary
  • Ovarian cyst
  • Abnormality of the menstrual cycle
  • Polycystic ovaries
  • Abnormality of the musculoskeletal system
  • Abnormal liver morphology
  • Abnormality of the nervous system
  • Abnormality of the breast
  • Gynecomastia
  • Abnormality of the endocrine system
  • Diabetes mellitus
  • Insulin-resistant diabetes mellitus
  • Insulin resistance

AKT2 Localizations – Subcellular Localization Database

Emw. Structure of the AKT2 protein. Based on PyMOL rendering of PDB 1gzk.

Gene Location