This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

  • Nucleotide binding
  • Protein kinase activity
  • Enables NF-kappaB-inducing kinase activity
  • Enables protein serine/threonine/tyrosine kinase activity
  • Enables protein tyrosine kinase activity
  • Located in plasma membrane
  • Located in integral component of plasma membrane
  • Membrane
  • Integral component of membrane
  • Part of protein-containing complex
  • Protein phosphorylation
  • Involved in signal transduction
  • Involved in transmembrane receptor protein tyrosine kinase signaling pathway
  • Involved in multicellular organism development
  • Nervous system development
  • Neuroblastoma 3
  • Neuroblastoma
  • Inflammatory Myofibroblastic Tumor
  • Alk-Positive Anaplastic Large Cell Lymphoma
  • Alk-Positive Large B-Cell Lymphoma
  • Rhabdomyosarcoma
  • Neuroblastoma 1
  • Differentiated Thyroid Carcinoma
  • Lung Cancer
  • Lymphoma
  • Anaplastic Large Cell Lymphoma
  • Epithelioid Inflammatory Myofibroblastic Sarcoma
  • Peripheral T-Cell Lymphoma
  • Reticulosarcoma
  • Brain Cancer
  • Lung Sarcomatoid Carcinoma
  • Alk-Negative Anaplastic Large Cell Lymphoma
  • Lung Non-Squamous Non-Small Cell Carcinoma
  • Lung Squamous Cell Carcinoma

ALK Localizations – Subcellular Localization Database

A2-33Own work. HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB.

Gene Location