Personalized Alzheimer’s Disease Risk

Actionable Biomarkers Identify Genetic Fingerprints to Help Determine Your Personal Risk Profile

Alzhemier genetic testing is a single gene test that looks at your ApoE-related genetic risk for Alzheimer’s disease.Your test results will explain which combination of ApoE alleles you have. This genetic combination will help you identify your ApoE-related genetic risk for developing Alzheimer’s disease, based on your ApoE genotype.
E4/E4 carries the highest risk and may increase risk up to 12 fold with an earlier age of disease onset.8 The APOE4 variant is implicated in 40% of Alzheimer’s cases.

Mounting evidence suggests that APOE E4 isoform contributes to Alzheimer’s disease pathogenesis through multiple pathways including facilitated amyloid-β peptide deposition, lipid transport neuroinflammation, and cerebrovascular defects. The association of one or two copies of the APOE allele ε4 (i.e., genotypes ε2/ε4, ε3/ε4, ε4/ε4) with late-onset Alzheimer disease is well documented. The strongest association between the APOE ε4 allele and late onset Alzheimer’s disease, relative to the normal control population, is observed with the ε4/ε4 genotype This genotype occurs in 1% of the normal control population and in 19% of the familial late onset Alzheimer’s disease population. The association between APOE e4 and Alzheimer disease is greatest when the individual has a positive family history of dementia.

Who can benefit from this test?

– Any one who wants to know their genetic risk for Alzheimers
– If you have a relative who has been determined to have Alzheimer’s or some other type of dementia, you are likely worried about your very own hazard as well.
– Families share a living situation and way of life, not withstanding their hereditary qualities.
– Scientists accept late-beginning Alzheimer’s illness (happening in the mid-60’s and more seasoned) includes a blend of hereditary qualities, way of life, and condition.
– A family ancestry of Alzheimer’s does not imply that you will build up the sickness, however it might imply that you are bound to create it.

Alzheimer’s Disease Risk

Apolipoprotein E (APOE)

This test is an array-based assay that screens two variants in APOE gene associated with Alzheimer pre disposition. This is not a diagnostic test for Alzheimer’s; it only reports the genetic alterations associated with the two variants tested.

If you have any questions about Personalized Alzheimer’s disease risk at Ayass BioScience, LLC, please call today at 972-668-6005 or fill out our contact form on the bottom of this page. We will answer any question you might have.