This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
Tumor type associations:
- Bladder
- Breast
- Cervical
- Colorectal
- Endometrial
- Esophageal
- Gastric
- Kidney
- Liver
- Melanoma
- Ovarian
- Pancreatic
- Prostate
- Located in kinetochore
- Located in nucleus
- Located in nucleoplasm
- Located in cytoplasm
- Located in Golgi apparatus
- Enables protein binding
- Enables beta-catenin binding
- Enables microtubule binding
- Enables protein kinase regulator activity
- Enables protein kinase binding
- Acts upstream of or within mitotic cytokinesis
- Involved in cell fate specification
- Involved in cellular response to DNA damage stim
- Acts upstream of or within negative regulation of microtubule depolymerization
- Acts upstream of or within mitotic spindle assembly checkpoint signaling
- Adenoma, periampullary, somatic
- Adenomatous polyposis coli
- Brain tumor-polyposis syndrome 2
- Colorectal cancer, somatic
- Desmoid disease, hereditary
- Gardner syndrome
- Gastric adenocarcinoma and proximal polyposis of the stomach
- Gastric cancer, somatic
- Hepatoblastoma, somatic
APC Localizations – Subcellular Localization Database
The original uploader was ProteinBoxBot. Structure of the APC protein.
