Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3’UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

  • Retinoid metabolic process
  • Innate immune response in mucosa
  • Cholesterol biosynthetic process
  • Lipid transport
  • Response to lipid hydroperoxide
  • Carotenemia
  • Familial hypercholesterolemia
  • Amyloidosis, familial visceral
  • Hyperlipidemia, familial combined, 3
  • Hypobetalipoproteinemia, familial, 1

APOA4 Localizations – Subcellular Localization Database

Gene Location