![APOE-d](https://ayassbioscience.com/wp-content/uploads/2020/10/APOE-d.png)
![APOE-b](https://ayassbioscience.com/wp-content/uploads/2020/10/APOE-b.png)
A structural model of the 22k fragment of apolipoprotein E4 based on data from Dong J, Peters-Libeu CA, Weisgraber KH, Segelke BW, Rupp B, Capila I, Hernaiz MJ, LeBrun LA, and Linhardt RJ (2001). Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. 40: 2826-2834. DOI: 10.1021/bi002417n. Data accessed from the protein data bank at https://www.rcsb.org/structure/1B68 and modeled using PyMOL.
.Gene Location
![APOE-a](https://ayassbioscience.com/wp-content/uploads/2020/10/APOE-a.png)
Pathogenic Prevalence
% 5.15832482124617
Ratio of samples with at least 1 pathogenic variant (Computed from Ayass Bioscience Samples)
HM-VUS Prevalence
% 0.255362614913177
Ratio of samples with at least 1 High/Med VUS variant (Computed from Ayass Bioscience Samples)
![APOE-c](https://ayassbioscience.com/wp-content/uploads/2020/10/APOE-c.png)