The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

  • Nucleotide binding
  • Enables virus receptor activity
  • Enables phosphatidylserine binding
  • Protein kinase activity
  • Enables protein serine/threonine/tyrosine kinase activity
  • Located in extracellular space
  • Located in plasma membrane
  • Is active in integral component of plasma membrane
  • Located in cell surface
  • Located in actin cytoskeleton
  • Involved in neuron migration
  • Involved in natural killer cell differentiation
  • Negative regulation of cytokine production
  • Involved in positive regulation of cytokine-mediated signaling pathway
  • Involved in blood vessel remodeling
  • Autosomal recessive inheritance
  • Cryptorchidism
  • Abnormality of male external genitalia
  • Abnormal testis morphology
  • Abnormal penis morphology
  • Hypogonadotropic hypogonadism
  • Hypoplastic male external genitalia
  • Micropenis
  • Abnormality of the genital system
  • Abnormality of reproductive system physiology
  • Abnormality of the genitourinary system
  • Hypogonadism
  • Abnormality of the menstrual cycle
  • Amenorrhea
  • Decreased fertility
  • Abnormality of the breast
  • Gynecomastia
  • Primary amenorrhea
  • Infertility

AXL Localizations – Subcellular Localization Database

EmwStructure of the AXL protein. Based on PyMOL rendering of PDB 2c5d.

Gene Location