The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]
- Nucleotide binding
- Enables virus receptor activity
- Enables phosphatidylserine binding
- Protein kinase activity
- Enables protein serine/threonine/tyrosine kinase activity
- Located in extracellular space
- Located in plasma membrane
- Is active in integral component of plasma membrane
- Located in cell surface
- Located in actin cytoskeleton
- Involved in neuron migration
- Involved in natural killer cell differentiation
- Negative regulation of cytokine production
- Involved in positive regulation of cytokine-mediated signaling pathway
- Involved in blood vessel remodeling
- Autosomal recessive inheritance
- Cryptorchidism
- Abnormality of male external genitalia
- Abnormal testis morphology
- Abnormal penis morphology
- Hypogonadotropic hypogonadism
- Hypoplastic male external genitalia
- Micropenis
- Abnormality of the genital system
- Abnormality of reproductive system physiology
- Abnormality of the genitourinary system
- Hypogonadism
- Abnormality of the menstrual cycle
- Amenorrhea
- Decreased fertility
- Abnormality of the breast
- Gynecomastia
- Primary amenorrhea
- Infertility
AXL Localizations – Subcellular Localization Database
. Structure of the AXL protein. Based on PyMOL rendering of PDB 2c5d.
Gene Location
