BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

  • Autophagosome assembly
  • Protein folding
  • Apoptotic process
  • Brain development
  • Extrinsic apoptotic signaling pathway via death domain receptors
  • Myopathy, myofibrillar, 6
  • Cardiomyopathy, dilated, 1hh
  • Cardiomyopathy, dilated, 1b
  • Charcot-marie-tooth disease/hereditary motor and sensory neuropathy
  • Dilated cardiomyopathy

BAG3 localizations – Subcellular Localization Database

Emw. Structure of the BAG3 protein. Based on PyMOL rendering of PDB 1uk5.

Gene Location