CD10 – Cluster of Differentiation 10
CALLA – Common Acute Lymphocytic Leukemia Antigen
MME – Membrane Metallo-Endopeptidase
NEP – Neutral Endopeptidase
A type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids; expressed in acute lymphocytic leukemia and follicular-center-cell lymphomas. Cell membrane metallopeptidase widely distributed in hematopoietic cells and their neoplasms. Important in diagnosis of preB-AL.
Reactivity: Follicle center cells, Follicular Lymphoma (FL), some Diffuse Large B-cell Lymphoma (DLBCL), Acute B Lymphoblastic Leukemia (pre-B-ALL), Acute T Lymphoblastic Leukemia/Lymphoma (pre-T-ALL), thymocytes, Burkitt’s Lymphoma (BL).
The structure of neprilysin, a zinc metalloprotease involved in the metabolism of extracellular regulatory peptides such as the enkephalins and substance P. Neprilysin in neural tissue is the major protease degrading amyloid beta, a peptide fragment whose abnormal misfolding and aggregation is associated with Alzheimer’s disease. The gray sphere represents a zinc atom; the green structure is a zinc-chelating enzyme inhibitor. (Opabinia regalis. Self-created from PDB ID 1R1H using PyMol)