CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Lung Cancer Susceptibility 3 and Adenosquamous Prostate Carcinoma. Among its related pathways are DNA Damage and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.

Tumor type associations:

  • Bladder
  • Breast
  • Cervical
  • Colorectal
  • Endometrial
  • Esophageal
  • Gastric
  • Kidney
  • Melanoma
  • Ovarian
  • Pancreatic
  • Prostate
  • Nucleotide binding
  • Enables protein kinase activity
  • Protein serine/threonine kinase activity
  • Enables cyclin-dependent protein serine/threonine kinase activity
  • Enables protein serine/threonine/tyrosine kinase activity
  • Part of cyclin-dependent protein kinase holoenzyme complex
  • Part of cyclin K-CDK12 complex
  • Is active in nucleus
  • Located in nucleoplasm
  • Part of cyclin/CDK positive transcription elongation factor complex
  • Involved in transcription elongation from RNA polymerase II promote
  • Involved in mRNA processing
  • Involved in protein phosphorylation
  • Involved in RNA splicing
  • Phosphorylation

CDK12 localizations – Subcellular Localization Database

Gene Location