This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5′ UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

  • Regulation of the force of heart contraction
  • Cardiac muscle hypertrophy
  • Cellular calcium ion homeostasis
  • Inflammatory response
  • Multicellular organism development
  • Cardiomyopathy, familial hypertrophic, 12
  • Cardiomyopathy, dilated, 1m
  • Dilated cardiomyopathy
  • Familial isolated dilated cardiomyopathy
  • Hypertrophic cardiomyopathy

Structure of protein CSRP3.Based on PyMOL rendering of PDB 2O10.

Gene Location