The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Tumor type associations:

  • Bladder
  • Cervical
  • Colorectal
  • Endometrial
  • Gastric
  • Liver
  • Melanoma
  • Ovarian
  • Pancreatic
  • Prostate
  • Enables transcription coregulator binding
  • Enables chromatin binding
  • Enables transcription coactivator activity
  • Enables protein binding
  • Enables beta-catenin binding
  • Located in euchromatin
  • Located in spindle pole
  • Located in nucleus
  • Located in nucleoplasm
  • Part of transcription regulator complex
  • Involved in negative regulation of transcription by RNA polymerase II
  • Involved in protein polyubiquitination
  • Involved in embryonic axis specification
  • Involved in cell morphogenesis involved in differentiation
  • Skeletal system development
  • Colorectal cancer, somatic
  • Exudative vitreoretinopathy 7
  • Hepatocellular carcinoma, somatic
  • Medulloblastoma, somatic
  • Neurodevelopmental disorder with spastic diplegia and visual defects
  • Ovarian cancer, somatic
  • Pilomatricoma, somatic

CTNNB1 localizations – Subcellular Localization Database

Three-dimensional structure of the armadillo repeat region of beta-catenin. Huber, A.H., Nelson, W.J., Weis, W.I. Journal: (1997) Cell(Cambridge,Mass.) 90: 871-882. Link.

Gene Location