The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]

  • Dolichyl diphosphate biosynthetic process
  • Phosphorylation
  • Dolichyl monophosphate biosynthetic process

  • Congenital disorder of glycosylation, type im
  • Familial isolated dilated cardiomyopathy
  • Congenital disorder of glycosylation, type ie
  • Congenital disorder of glycosylation, type iik
  • Immunodeficiency 47

DOLK (dolichol kinase) – BioGPS

Interacting Proteins for DOLK Gene – String

DOLK Localizations – Subcellular Localization Database

Gene Location