The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]

  • Nucleotide binding
  • Enables virus receptor activity
  • Enables chromatin binding
  • Enables double-stranded DNA binding
  • Protein kinase activity
  • Located in Golgi membrane
  • Extracellular region
  • Located in extracellular space
  • Located in nucleus
  • Located in cytoplasm
  • Involved in MAPK cascade
  • Involved in cell morphogenesis
  • Involved in ossification
  • Involved in embryonic placenta development
  • Involved in positive regulation of protein phosphorylation
  • Inflammatory Skin And Bowel Disease, Neonatal, 2
  • Lung Cancer
  • Lung Cancer Susceptibility 3
  • Lung Squamous Cell Carcinoma
  • Giant Cell Glioblastoma
  • Gliosarcoma
  • Neonatal Inflammatory Skin And Bowel Disease
  • Cowden Syndrome 1
  • Brain Stem Glioma
  • Brain Cancer
  • Adenocarcinoma
  • Adenosquamous Carcinoma
  • Endometrial Adenocarcinoma
  • Vulva Cancer
  • Oral Cavity Cancer
  • Bile Duct Cancer
  • Squamous Cell Carcinoma
  • Glioblastoma
  • Adenosquamous Lung Carcinoma
  • Oligodendroglioma
  • Bronchiolo-Alveolar Adenocarcinoma
  • Salivary Gland Carcinoma
  • Penile Cancer
  • Autosomal dominant inheritance
  • Autosomal recessive inheritance
  • Abnormality of head or neck
  • Abnormality of the mouth
  • Abnormal lip morphology
  • Abnormal oral cavity morphology
  • Abnormality of the head
  • Abnormality of the face
  • Abnormality of the orbital region
  • Abnormality of the outer ear
  • Abnormality of the nose
  • Abnormality of the auditory canal
  • Abnormal pharynx morphology
  • Otitis externa
  • Abnormality of the eye
  • Abnormal eyelid morphology
  • Blepharitis
  • Abnormal eyelash morphology
  • Long eyelashes
  • Abnormal eyebrow morphology
  • Abnormality of the ear
  • Abnormality of the pharynx
  • Hypertension
  • Abnormality of the skin
  • Edema
  • Somatic mutation
  • Growth abnormality

EGFR Localizations – Subcellular Localization Database

BoghogOwn work. Cartoon diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed its ligand epidermal growth factor (magenta) based on the PDB: 1NQL​ crystallographic coordinates.

Gene Location