This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
- Regulation of membrane depolarization
- Multicellular organism development
- Muscle organ development
- Animal organ morphogenesis
- Negative regulation of G2/M transition of mitotic cell cycle
- Myopathy, x-linked, with postural muscle atrophy
- Scapuloperoneal myopathy, x-linked dominant
- Reducing body myopathy, x-linked 1a, severe, with infantile or early childhood onset
- Reducing body myopathy, x-linked 1b, with late childhood or adult onset
- Uruguay faciocardiomusculoskeletal syndrome
FHL1 Localizations – Subcellular Localization Database
Gene Location
