This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

  • Negative regulation of transcription by RNA polymerase II
  • Osteoblast differentiation
  • Regulation of transcription by RNA polymerase II
  • Response to hormone
  • Regulation of lipid metabolic process
  • Familial isolated dilated cardiomyopathy
  • Rhabdomyosarcoma
  • Hemophagocytic lymphohistiocytosis, familial, 1
  • Hemophagocytic lymphohistiocytosis
  • Deafness, autosomal recessive 65

Emw. Structure of the FHL2 protein. Based on PyMOL rendering of PDB 1x4k.

Gene Location