This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

Tumor type associations:

  • Bladder
  • Breast
  • Colorectal
  • Endometrial
  • Prostate

  • Enables transcription cis-regulatory region binding
  • Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • Enables DNA-binding transcription factor activity, RNA polymerase II-specific
  • Enables DNA-binding transcription activator activity, RNA polymerase II-specific
  • Enables DNA binding
  • Located_in chromatin
  • Located_in fibrillar center
  • Located_in nucleus
  • Located_in nucleoplasm
  • Located_in microvillus
  • Involved_in negative regulation of transcription by RNA polymerase II
  • Chromatin organization
  • Involved_in chromatin remodeling
  • Regulation of transcription, DNA-templated
  • Involved_in regulation of transcription by RNA polymerase II

FOXA1 (forkhead box A1) – BioGPS

Interacting Proteins for FOXA1 Gene – String

FOXA1 localizations – Subcellular Localization Database

Gene Location