The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]

  • Regulation of heart rate
  • Carbohydrate metabolic process
  • Glycerol-3-phosphate metabolic process
  • NOT NADH oxidation
  • Phosphatidic acid biosynthetic process
  • Brugada syndrome 2
  • Brugada syndrome
  • Sudden infant death syndrome
  • Right bundle branch block
  • Long qt syndrome

GPD1L Localizations – Subcellular Localization Database