This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

  • Regulation of heart rate
  • Regulation of membrane depolarization
  • Ion transport
  • Cation transport
  • Potassium ion transport
  • Sick sinus syndrome 2
  • Brugada syndrome 8
  • Familial sick sinus syndrome
  • Brugada syndrome
  • Sick sinus syndrome

Emw. Structure of the HCN4 protein. Based on PyMOL rendering of PDB 1q3e.

Gene Location