The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]
- Angiogenesis
- Cell fate determination
- Negative regulation of cell-matrix adhesion
- Blood vessel remodeling
- Morphogenesis of an epithelial sheet
- Alagille syndrome 1
- Deafness, congenital heart defects, and posterior embryotoxon
- Tetralogy of fallot
- Atypical coarctation of aorta
- Rare congenital non-syndromic heart malformation
JAG1 Localizations – Subcellular Localization Database
Structure of protein JAG1.Based on PyMOL rendering of PDB 2KB9. Pleiotrope.
Gene Location
