This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]

  • Ion transport
  • Potassium ion transport
  • Regulation of ion transmembrane transport
  • Regulation of heart rate by cardiac conduction
  • Membrane repolarization during atrial cardiac muscle cell action potential
  • Hyperaldosteronism, familial, type iii
  • Long qt syndrome 13
  • Andersen cardiodysrhythmic periodic paralysis
  • Long qt syndrome 1
  • Osteoarthritis

KCNJ5 Localizations – Subcellular Localization Database

Gene Location