This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

  • Negative regulation of transcription by RNA polymerase II
  • Regulation of transcription, DNA-templated
  • Regulation of transcription by RNA polymerase II
  • Cell-cell signaling
  • Circadian rhythm
  • Hemoglobinopathy
  • Pancreatic cancer
  • Pancreatic adenocarcinoma
  • Hypertrophic cardiomyopathy
  • Osteoporosis

Gene Location