This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

  • MAPK cascade
  • Liver development
  • Positive regulation of protein phosphorylation
  • Stimulatory C-type lectin receptor signaling pathway
  • Signal transduction
  • Oculoectodermal syndrome
  • Noonan syndrome 3
  • Cardiofaciocutaneous syndrome 2
  • Schimmelpenning-feuerstein-mims syndrome
  • Arteriovenous malformations of the brain

Thomas Splettstoesser. Pepresentation of the crystal structure of Kirsten rat sarcoma viral oncogene homolog (KRAS), based on PDB 3GFT. Shown in stick representation is the GTP analogue.

Gene Location