This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Tumor type associations:

  • Bladder
  • Breast
  • Cervical
  • Colorectal
  • Endometrial
  • Esophageal
  • Gastric
  • Kidney
  • Liver
  • Lymphoma
  • Melanoma
  • Ovarian
  • Pancreatic
  • Prostate
  • Involved in MAPK cascade
  • Involved in positive regulation of protein phosphorylation
  • Signal transduction
  • Involved in Ras protein signal transduction
  • Involved in positive regulation of cell population proliferation
  • Located in Golgi membrane
  • Located in cytoplasm
  • Located in mitochondrial outer membrane
  • Located in endoplasmic reticulum membrane
  • Located in cytosol
  • Nucleotide binding
  • Enables GTPase activity
  • Enables G protein activity
  • Enables protein binding
  • Enables GTP binding
  • Oculoectodermal syndrome
  • Noonan syndrome 3
  • Cardiofaciocutaneous syndrome 2
  • Schimmelpenning-feuerstein-mims syndrome
  • Arteriovenous malformations of the brain
  • Bladder cancer
  • Breast cancer
  • Gastric cancer
  • Leukemia, acute myeloid
  • Lung cancer
  • Pancreatic carcinoma
  • RAS-associated autoimmune leukoproliferative disorder

Thomas Splettstoesser. Pepresentation of the crystal structure of Kirsten rat sarcoma viral oncogene homolog (KRAS), based on PDB 3GFT. Shown in stick representation is the GTP analogue.

Gene Location