The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Tumor type associations:

  • Bladder
  • Breast
  • Cervical
  • Colorectal
  • Endometrial
  • Gastric
  • Kidney
  • Liver
  • Lymphoma
  • Melanoma
  • Prostate
  • Rnables RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • Enables chromatin binding
  • Enables transcription coregulator activity
  • Enables transcription coactivator activity
  • Enables protein binding
  • Part of ubiquitin ligase complex
  • Located in nucleus
  • Located in nucleoplasm
  • Located in membrane
  • Part of mediator complex
  • Somitogenesis
  • Involved in neural tube closure
  • Involved in regulation of transcription by RNA polymerase II
  • Involved in endoderm development
  • Involved in heart development
  • Hardikar syndrome
  • Lujan-Fryns syndrome
  • Ohdo syndrome, X-linked
  • Opitz-Kaveggia syndrome

MED12 localizations – Subcellular Localization Database

Gene Location