This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
- Lipodystrophy, congenital generalized, type 4
- Spinal muscular atrophy with lower extremity predominance
- Dilated cardiomyopathy
