Late Onset Familial Alzheimer’s Disease
Genes: APOE e4, ACE, PICALM
Late-onset Alzheimer’s disease is a condition characterized by memory loss, cognitive decline, and personality changes developing after the age of 65. One in ten Americans age 65 and older is affected by Alzheimer’s disease.
The most important risk factor for Alzheimer’s disease is a gene called Apolipoprotein E, or APOE. This gene has a number of different alleles (alternative form of a gene, one member of a pair), called ε2, ε3, and ε4. ε2 and ε3 protect against Alzheimer’s, whereas ε4 increases your risk of developing it. Every individual has two copies of this allele, and the combination you have determines how likely you are to develop the disease.