This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

MAPK cascade
Positive regulation of endothelial cell proliferation
Stimulatory C-type lectin receptor signaling pathway
Signal transduction
Ras protein signal transduction

  • Ras-associated autoimmune leukoproliferative disorder
  • Melanocytic nevus syndrome, congenital
  • Noonan syndrome 6
  • Melanosis, neurocutaneous
  • Nevus, epidermal

Emw. Structure of the NRAS protein. Based on PyMOL rendering of PDB 121p.

Gene Location