The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]

  • Actin filament organization
  • Heart development
  • Actin cytoskeleton organization
  • Muscle structure development
  • Cardiomyopathy, dilated, 1dd
  • Facioscapulohumeral muscular dystrophy 1
  • Hypertrophic cardiomyopathy
  • Osteitis fibrosa
  • Dilated cardiomyopathy

Emw. Structure of the PDLIM3 protein. Based on PyMOL rendering of PDB 1v5l.

Gene Location