The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
FUNCTION
- Nucleotide binding
- Enables magnesium ion binding
- Protein kinase activity
- Enables protein serine/threonine kinase activity
- Enables AMP-activated protein kinase activity
LOCALIZATION
- Is active in nucleus
- Located in nucleoplasm
- Cytoplasm
- Located in centrosome
- Located in cytosol
PATHWAYS & INTERACTION
- Involved in neural tube closure
- Involved in renal water homeostasis
- Involved in protein phosphorylation
- Involved in signal transduction
- Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- Autosomal dominant inheritance
- Abnormality of head or neck
- Abnormality of the mouth
- Abnormal lip morphology
- Abnormal oral cavity morphology
- Abnormality of the dentition
- Abnormality of upper lip
- Abnormal oral frenulum morphology
- Accessory oral frenulum
- Abnormality of the head
- Abnormality of the face
- Long face
- Abnormality of the mandible
- Abnormality of the philtrum
- Abnormality of the forehead
- Mandibular prognathia
- Abnormality of the chin
- Hypertelorism
- Short philtrum
- Broad forehead
- Abnormality of the musculoskeletal system
- Abnormality of the nose
- Abnormality of the nasal tip
- Abnormality of the eye
- Abnormal blood vessel morphology
- Bilateral superior vena cava
PRKACB Localizations – Subcellular Localization Database
Gene Location
