The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]


  • Nucleotide binding
  • Enables magnesium ion binding
  • Protein kinase activity
  • Enables protein serine/threonine kinase activity
  • Enables AMP-activated protein kinase activity


  • Is active in nucleus
  • Located in nucleoplasm
  • Cytoplasm
  • Located in centrosome
  • Located in cytosol


  • Involved in neural tube closure
  • Involved in renal water homeostasis
  • Involved in protein phosphorylation
  • Involved in signal transduction
  • Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  • Autosomal dominant inheritance
  • Abnormality of head or neck
  • Abnormality of the mouth
  • Abnormal lip morphology
  • Abnormal oral cavity morphology
  • Abnormality of the dentition
  • Abnormality of upper lip
  • Abnormal oral frenulum morphology
  • Accessory oral frenulum
  • Abnormality of the head
  • Abnormality of the face
  • Long face
  • Abnormality of the mandible
  • Abnormality of the philtrum
  • Abnormality of the forehead
  • Mandibular prognathia
  • Abnormality of the chin
  • Hypertelorism
  • Short philtrum
  • Broad forehead
  • Abnormality of the musculoskeletal system
  • Abnormality of the nose
  • Abnormality of the nasal tip
  • Abnormality of the eye
  • Abnormal blood vessel morphology
  • Bilateral superior vena cava

PRKACB Localizations – Subcellular Localization Database

Emw Own workStructure of the PRKACB protein. Based on PyMOL rendering of PDB 1apm.

Gene Location